Hydroxyquinoline Sulfate

Hydroxyquinoline Sulfate

Drug Nomenclature

Date of monograph revision: 24-Mar-1998; 01-Sep-1998; 01-Feb-2001; 09-Nov-2001; 17-Jun-2004; 25-Jul-2006
Synonyms: Chinosolum; Hidroxiquinolina, sulfato de; Hydroxyquinoline Sulphate; Oksikinoliinisulfaatti; Oxichinolini Sulfas; Oxikinolinsulfat; Oxine Sulphate; Oxyquinol; Sulfate d'Orthoxyquinoléine
USAN: Oxyquinoline Sulfate
Chemical name: Quinolin-8-ol sulphate; 8-Quinolinol sulphate
Molecular formula: (C9H7NO)2,H2SO4 =388.4
CAS: 148-24-3 (hydroxyquinoline); 134-31-6 (hydroxyquinoline sulfate)
ATC code: A01AB07; D08AH03; G01AC30; R02AA14
Chemical Structure of Hydroxyquinoline

Chemical Structure of Hydroxyquinoline

Pharmacopoeias:

In Fr. and Swiss. Also in USNF.

USNF 24 (Oxyquinoline Sulfate). A yellow powder. Very soluble in water; slightly soluble in alcohol; practically insoluble in acetone and in ether; freely soluble in methyl alcohol.

Potassium Hydroxyquinoline Sulfate

Drug Nomenclature

Date of monograph revision: 02-Apr-1998; 06-Oct-1998; 24-Jan-2001; 14-Nov-2001; 07-Jul-2004; 25-Jul-2006
Synonyms: Oxiquinol potásico; Oxyquinol Potassium; Potassii Hydroxyquinolini Sulphas; Potassium Hydroxyquinoline Sulphate; Potassium Oxyquinoline Sulphate
CAS: 14534-95-3
Chemical Structure of Hydroxyquinoline

Chemical Structure of Hydroxyquinoline

Pharmacopoeias:

In Br., Fr., and Ger.

BP 2005 (Potassium Hydroxyquinoline Sulphate). An equimolecular mixture of potassium sulfate and quinolin-8-ol sulfate monohydrate. It contains 50.6 to 52.6% of quinolin-8-ol and 29.5 to 32.5% of potassium sulfate, calculated with reference to the anhydrous substance. A pale yellow, odourless or almost odourless, microcrystalline powder. Freely soluble in water; insoluble in ether. On extraction with hot dehydrated alcohol a residue of potassium sulfate and a solution of quinolin-8-ol sulfate are obtained.

Drug Profile

Hydroxyquinoline sulfate and potassium hydroxyquinoline sulfate have antibacterial, antifungal, and deodorant properties, and have been used similarly in the topical treatment of skin, oropharyngeal, and vaginal disorders. Potassium hydroxyquinoline sulfate is often used with benzoyl peroxide.

Derivatives of hydroxyquinoline including the salicylate, benzoate, borate, hydrofluoride, iodochloride, silicofluoride, and sodium hydroxyquinoline sulfate have been used similarly.

Preparations

Single-ingredient Preparations

The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.

Brazil: Oto-Cer¤; Canada: Trimo-San¤; France: Rivacide¤; Serorhinol¤; Germany: Leioderm; Italy: Aftir Shampoo; Bio-Frin¤; Oxynol¤; Netherlands: Superol;

Multi-ingredient Preparations

The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.

Argentina: Curisept¤; Australia: Aci-Jel¤; Sedaural¤; Austria: Racestyptin¤; Belgium: Aseptosyl; Brazil: Andolba; Cerumin; Colpolase; Gynaseptol¤; Higienex¤; Lacto Vagin; Lacto-Gin¤; Leucocida; Lisofenicol¤; Lisoquinol¤; Nestosyl¤; Pan-Emecort¤; Senol; Varigerm¤; Canada: Aci-Jel¤; Dermoplast¤; Gyn-O-San¤; Chile: Diproquin; Czech Republic: Aviril H; France: Chromargon; Cones Rendell¤; Dermacide; Dermster¤; Nestosyl; Nestosyl; Germany: Antimycoticum¤; Chinomint Plus¤; Chinosol S Vaseline¤; Chinosol; Leioderm P; Nasalgon¤; Onychofissan¤; Hungary: Germicid; Ireland: Quinocort¤; Quinoderm; Valderma¤; Italy: Disinfene; Leucorsan¤; Neo Foille Pomata Disinfettante¤; Polvere Disinfettante¤; Ustiosan; Viderm¤; Netherlands: Creme bij Wondjes¤; New Zealand: Aci-Jel¤; Portugal: Apyrol¤; Russia: Contraceptin T (Контрацептин Т); South Africa: Auralgicin¤; Cuticura¤; Dermoplast¤; Oto-Phen Forte; Quinoderm-H¤; Quinoderm; Universal Earache Drops; Spain: Neodesfila¤; Stoma Anestesia Dental¤; Sweden: Aci-Jel¤; Switzerland: Benzocaine PD; Nasello¤; Quinoderm Hydrocortisone¤; Quinoderm¤; Racestyptine¤; Rectoseptal-Neo bismuthe; Rectoseptal-Neo simple; United Kingdom: Auralgicin¤; Quinocort¤; Quinoderm with Hydrocortisone¤; Quinoderm; Quinoped¤; Valderma; United States: Aci-Jel¤; Acid Jelly; Analgesic Otic Solution¤; Auroguard Otic; Cuticura¤; Fem pH; Medicone Derma-HC¤; Medicone Derma¤; Medicone Dressing¤; Oxyzal; Sanitube¤; Stypto-Caine; Trimo-San; Triv; Venezuela: Borogin; Fluquinol;



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