Estriol

Estriol

Drug Nomenclature

Date of monograph revision: 01-Oct-1997; 04-Jun-1998; 02-Nov-1999; 03-Sep-2001; 01-Nov-2002; 24-May-2006; (last modified: 04-Jun-2006)
Synonyms: Ösztriol; Estriol; Estrioli; Estriolis; Estriolum; Follicular Hormone Hydrate; Oestriol; Theelol
BAN: Estriol
Chemical name: Estra-1,3,5(10)-triene-3,16α,17β-triol
Molecular formula: C18H24O3 =288.4
CAS: 50-27-1
ATC code: G03CA04
Read code: y00UE [Gynaecological Use]; y08DX [Endocrine]
Chemical Structure of Estriol

Chemical Structure of Estriol

Pharmacopoeias:

In Eur. (see Go to European Pharmacopoeia Convention Signatories), Jpn, and US.

Ph. Eur. 5.5 (Estriol). A white or almost white crystalline powder. Practically insoluble in water; sparingly soluble in alcohol.

USP 29 (Estriol). A white or practically white, odourless, crystalline powder. Insoluble in water; sparingly soluble in alcohol; soluble in acetone, in chloroform, in dioxan, in ether, and in vegetable oils. Store in airtight containers.

Estriol Sodium Succinate

Drug Nomenclature

Date of monograph revision: 01-Oct-1997; 04-Jun-1998; 02-Nov-1999; 03-Sep-2001; 01-Nov-2002; 24-May-2006; (last modified: 04-Jun-2006)
Synonyms: Estriol, succinato sódico de; Oestriol Sodium Succinate
BAN: Estriol Sodium Succinate
INN: Estriol Sodium Succinate [rINNM (en)]
INN: Succinato sódico de estriol [rINNM (es)]
INN: Estriol, Succinate Sodique d' [rINNM (fr)]
INN: Estrioli Natrii Succinas [rINNM (la)]
INN: Естриола Натрия Сукцинат [rINNM (ru)]
Chemical name: Disodium 3-hydroxyestra-1,3,5(10)-triene-16α,17β-diyl disuccinate
Molecular formula: C26H30Na2O9 =532.5
CAS: 113-22-4
ATC code: G03CA04

Estriol Succinate

Drug Nomenclature

Date of monograph revision: 01-Oct-1997; 04-Jun-1998; 02-Nov-1999; 03-Sep-2001; 01-Nov-2002; 24-May-2006; (last modified: 04-Jun-2006)
Synonyms: Estriol, succinato de; Estrioli Succinas; Estriolisuksinaatti; Estriolsuccinat; Oestriol Succinate; Succinato de estriol
BAN: Estriol Succinate
INN: Estriol Succinate [rINN (en)]
INN: Succinato de estriol [rINN (es)]
INN: Estriol, Succinate d' [rINN (fr)]
INN: Estrioli Succinas [rINN (la)]
INN: Естриола Сукцинат [rINN (ru)]
Chemical name: 3-Hydroxyestra-1,3,5(10)-triene-16α,17β-diyl di(hydrogen succinate)
Molecular formula: C26H32O9 =488.5
CAS: 514-68-1
ATC code: G03CA04

Drug Profile

Estriol is a naturally occurring oestrogen with actions and uses similar to those described for estradiol (Go to Estradiol). It is claimed to have only a mild proliferative effect on the endometrium.

It is used for menopausal HRT (Go to Hormone Replacement Therapy). When oestrogens are given to women with a uterus, a progestogen is required, particularly if used long-term. For short-term treatment, doses of estriol by mouth have been 500 micrograms to 3 mg daily given for one month followed by 500 micrograms to 1 mg daily. Estriol has also been given with other natural oestrogens such as estradiol and estrone (see Go to Estrone); usual doses of estriol have ranged from about 250 micrograms to 2 mg daily. It is given intravaginally for the short-term treatment of menopausal atrophic vaginitis as a 0.01% or 0.1% cream or as pessaries containing 500 micrograms.

Estriol has also been given by mouth for infertility (Go to Infertility) caused by poor cervical penetration, in a dose of 250 micrograms to 1 mg daily on days 6 to 15 of the menstrual cycle.

Estriol succinate has also been given by mouth in the treatment of menopausal disorders. The sodium succinate salt has been used parenterally in the treatment of haemorrhage and thrombocytopenia.

Preparations

Single-ingredient Preparations

The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.

Argentina: Colpoestriol; Orgestriol; Australia: Ovestin; Austria: Ortho-Gynest; Ovestin; Styptanon; Belgium: Aacifemine; Ortho-Gynest; Brazil: Ovestrion; Styptanon; Chile: Ovestin; Sinapause; Czech Republic: Ortho-Gynest; Ovestin; Denmark: Ovestin; Finland: Ovestin; Pausanol; France: Gydrelle; Ovestin¤; Physiogine; Synapause¤; Trophicreme; Germany: Cordes Estriol; Gynasan; Hormomed¤; Klimax-E¤; OeKolp; Oestrilir N¤; Oestro-Gynaedron M; Orgastyptin¤; Ortho-Gynest; Ovestin; Ovo-Vinces¤; Synapause E; Synapause¤; Vago-med¤; Xapro; Greece: Ovestin; Hong Kong: Ovestin¤; Hungary: Estrokad; Ortho-Gynest; Ovestin; India: Evalon; Ireland: Ortho-Gynest; Ovestin¤; Israel: Ortho-Gynest; Ovestin; Italy: Colpogyn; Ortho Gynest Depot; Ovestin; Trofogin; Japan: Estriel; Mexico: Ortho-Gynest; Ovestin; Sinapause; Netherlands: Ortho-Gynest¤; Ovestin¤; Synapause-E3; Norway: Ovesterin; New Zealand: Ovestin; Portugal: Ovestin; Pausigin; Synapausa; Russia: Ovestin (Овестин); South Africa: Synapause; Singapore: Ovestin¤; Spain: Ovestinon; Synapause¤; Sweden: Ovesterin; Triovex¤; Switzerland: Klimadoral¤; Oestro-Gynaedron Nouveau; Ortho-Gynest; Ovestin; Styptanon¤; Thailand: Ovestin; United Kingdom: Ortho-Gynest; Ovestin; Venezuela: Ortho-Gynest; Ovestin;

Multi-ingredient Preparations

The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.

Argentina: Tropivag Plus; Austria: Gynoflor; Belgium: Gynoflor; Czech Republic: Cyclo-Menorette; CycloOstrogynal; Gynoflor; France: Florgynal; Trophigil; Germany: Cyclo-Menorette; CycloOstrogynal; Gynoflor; Klimax-H Taeschner¤; NeoOstrogynal; Oestro-Dequavagyn¤; OestroTricho N¤; Oestrugol N¤; Hong Kong: Gyno-Flor E¤; Hormonin; Hungary: Cyclo-Menorette; Gynoflor; Italy: Estiamen B¤; Estiamen¤; Switzerland: Gynoflor; United Kingdom: Hormonin;



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