Dextromethorphan

Dextromethorphan

Drug Nomenclature

Date of monograph revision: 15-Oct-1997; 24-Jun-1998; 10-Apr-2000; 01-Nov-2001; 01-Jul-2004; 08-Feb-2005; 05-Jul-2006; (last modified: 24-Jul-2006)
Synonyms: Dekstrometorfaani; Dextromethorphanum; Dextrometorfan; Dextrometorfano
BAN: Dextromethorphan
INN: Dextromethorphan [pINN (en)]
INN: Dextrometorfano [pINN (es)]
INN: Dextrométhorphane [pINN (fr)]
INN: Dextromethorphanum [pINN (la)]
INN: Декстрометорфан [pINN (ru)]
Chemical name: (+)-3-Methoxy-9a-methylmorphinan; (9S,13S,14S)-6,18-Dideoxy-7,8-dihydro-3-O-methylmorphine
Molecular formula: C18H25NO =271.4
CAS: 125-71-3
ATC code: R05DA09
Chemical Structure of Dextromethorphan

Chemical Structure of Dextromethorphan

NOTE:

The following terms have been used as 'street names' (see Go to Street Names) or slang names for various forms of dextromethorphan:

Bromage; Brome; Dex; DXM; Tussin.

Pharmacopoeias:

In US.

USP 29 (Dextromethorphan). A practically white to slightly yellow, odourless, crystalline powder. Practically insoluble in water; freely soluble in chloroform. Store in airtight containers.

Dextromethorphan Hydrobromide

Drug Nomenclature

Date of monograph revision: 15-Oct-1997; 24-Jun-1998; 10-Apr-2000; 01-Nov-2001; 01-Jul-2004; 08-Feb-2005; 05-Jul-2006; (last modified: 24-Jul-2006)
Synonyms: Dekstrometorfaanihydrobromidi; Dekstrometorfano hidrobromidas; Dextromethorfan-hydrobromid monohydrát; Dextromethorphani Hydrobromidum; Dextromethorphani Hydrobromidum Monohydricum; Dextrometorfán-hidrobromid; Dextrometorfanhydrobromid; Dextrometorfano, hidrobromuro de
BAN: Dextromethorphan Hydrobromide [BANM]
INN: Dextromethorphan Hydrobromide [pINNM (en)]
INN: Hidrobromuro de dextrometorfano [pINNM (es)]
INN: Dextrométhorphane, Bromhydrate de [pINNM (fr)]
INN: Dextromethorphani Hydrobromidum [pINNM (la)]
INN: Декстрометорфана Гидробромид [pINNM (ru)]
Chemical name: Dextromethorphan hydrobromide monohydrate
Molecular formula: C18H25NO,HBr,H2O =370.3
CAS: 125-69-9 (anhydrous dextromethorphan hydrobromide) ; 6700-34-1 (dextromethorphan hydrobromide monohydrate)
ATC code: R05DA09
Read code: y00DO
Pharmacopoeias:

In Eur. (see Go to European Pharmacopoeia Convention Signatories), Int., Jpn, Pol., US, and Viet.

Ph. Eur. 5.5 (Dextromethorphan Hydrobromide). An almost white, crystalline powder. Sparingly soluble in water; freely soluble in alcohol. Protect from light.

USP 29 (Dextromethorphan Hydrobromide). Practically white crystals or crystalline powder having a faint odour. Soluble 1 in 65 of water; freely soluble in alcohol and in chloroform; insoluble in ether. pH of a 1% solution in water is between 5.2 and 6.5. Store in airtight containers.

Adverse Effects and Treatment

Adverse effects with dextromethorphan appear to be rare and may include dizziness and gastrointestinal disturbances. Excitation, confusion, and respiratory depression may occur after overdosage. Dextromethorphan has been subject to abuse, but there is little evidence of dependence of the morphine type.

General references.

  1. 1. Bem JL, Peck R. Dextromethorphan: an overview of safety issues. Drug Safety 1992; 7: 190–9. PubMed

Effects on the skin.

A fixed-drug reaction developed in a patient after ingestion of dextromethorphan 30 mg.1 Oral provocation with dextromethorphan produced a positive reaction but the results of topical application tests were negative.

  1. 1. Stubb S, Reitamo S. Fixed-drug eruption due to dextromethorphan. Arch Dermatol 1990; 126: 970–1. PubMed

Overdosage.

There have been reports1-6 of overdosage or accidental poisoning (usually in children) due to dextromethorphan, including rare fatalities. Naloxone may be effective in reversing toxicity. Extrapyramidal reactions were seen in a child who ingested dextromethorphan.6 Overdosage has also been associated with abuse (see Go to Abuse.).

  1. 1. Shaul WL, et al Dextromethorphan toxicity: reversal by naloxone. Pediatrics 1977; 59: 117–19. PubMed
  2. 2. Katona B, Wason S. Dextromethorphan danger. N Engl J Med 1986; 314: 993. PubMed
  3. 3. Rammer L, et al. Fatal intoxication by dextromethorphan: a report on two cases. Forensic Sci Int 1988; 37: 233–6. PubMed
  4. 4. Schneider SM, et al. Dextromethorphan poisoning reversed by naloxone. Am J Emerg Med 1991; 9: 237–8. PubMed
  5. 5. Pender ES, Parks BR. Toxicity with dextromethorphan-containing preparations: a literature review and report of two additional cases. Pediatr Emerg Care 1991; 7: 163–5. PubMed
  6. 6. Warden CR, et al. Dystonic reaction associated with dextromethorphan ingestion in a toddler. Pediatr Emerg Care 1997; 13: 214–15. PubMed

Precautions

Dextromethorphan should not be given to patients at risk of developing respiratory failure. Caution is needed in patients with a history of asthma and it should not be given during an acute attack.

Abuse.

Dextromethorphan has been abused,1-10 alone or with other drugs in over-the-counter preparations or as a powder sold under the name DXM.

  1. 1. Fleming PM. Dependence on dextromethorphan hydrobromide. BMJ 1986; 293: 597. PubMed
  2. 2. Orrell MW, Campbell PG. Dependence on dextromethorphan hydrobromide. BMJ 1986; 293: 1242–3.
  3. 3. Walker J, Yatham LN. Benylin (dextromethorphan) abuse and mania. BMJ 1993; 306: 896. PubMed
  4. 4. Wolfe TR, Caravati EM. Massive dextromethorphan ingestion and abuse. Am J Emerg Med 1995; 13: 174–6. PubMed
  5. 5. Nordt SP. DXM: a new drug of abuse? Ann Emerg Med 1998; 31: 794–5. PubMed
  6. 6. Cranston JW, Yoast R. Abuse of dextromethorphan. Arch Fam Med 1999; 8: 99–100. PubMed
  7. 7. Price LH, Lebel J. Dextromethorphan-induced psychosis. Am J Psychiatry 2000; 157: 304. PubMed
  8. 8. Noonan WC, et al. Dextromethorphan abuse among youth. Arch Fam Med 2000; 9: 791–2. PubMed
  9. 9. Banerji S, Anderson IB. Abuse of Coricidin HBP cough and cold tablets: episodes recorded by a poison center. Am J Health-Syst Pharm 2001; 58: 1811–14. PubMed
  10. 10. Food and Drug Administration. FDA warns against abuse of dextromethorphan (DXM) (issued 20 May 2005). Available at: online (accessed 05/05/06)

Children.

For doubts about the use of dextromethorphan as an antitussive in children see Cough, under Uses and Administration, Go to Cough..

Interactions

Severe and sometimes fatal reactions have been reported after use of dextromethorphan in patients receiving MAOIs. Dextromethorphan is primarily metabolised by the cytochrome P450 isoenzyme CYP2D6; the possibility of interactions with inhibitors of this enzyme, including amiodarone, fluoxetine, haloperidol, paroxetine, propafenone, quinidine, and thioridazine, should be borne in mind.

Antiarrhythmics.

Quinidine can increase serum concentrations of dextromethorphan markedly, and some patients have experienced symptoms of dextromethorphan toxicity when the two drugs have been used together.1,2 Based on this interaction, the combination has been studied for its therapeutic effect in amyotrophic lateral sclerosis (see Neurological Disorders, Go to Neurological disorders.). Amiodarone also appears to be able to increase serum concentrations of dextromethorphan.3

  1. 1. Zhang Y, et al. Dextromethorphan: enhancing its systemic availability by way of low-dose quinidine-mediated inhibition of cytochrome P4502D6. Clin Pharmacol Ther 1992; 51: 647–55. PubMed
  2. 2. Pope LE, et al. Pharmacokinetics of dextromethorphan after single or multiple dosing in combination with quinidine in extensive and poor metabolizers. J Clin Pharmacol 2004; 44: 1132–42. PubMed
  3. 3. Funck-Brentano C, et al. Influence of amiodarone on genetically determined drug metabolism in humans. Clin Pharmacol Ther 1991; 50: 259–66. PubMed

Antibacterials.

Serotonin syndrome-like symptoms have occurred when dextromethorphan has been taken with linezolid.

Antidepressants.

A patient receiving fluoxetine experienced visual hallucinations after she began taking dextromethorphan.1 The hallucinations were similar to those she had had 12 years earlier with lysergide. She had previously taken dextromethorphan alone without any adverse reactions. A serotonin syndrome (Go to Serotonin syndrome.) has been reported in a patient who took a cold-remedy containing dextromethorphan while receiving paroxetine.2

  1. 1. Achamallah NS. Visual hallucinations after combining fluoxetine and dextromethorphan. Am J Psychiatry 1992; 149: 1406. PubMed
  2. 2. Skop BP, et al. The serotonin syndrome associated with paroxetine, an over-the-counter cold remedy, and vascular disease. Am J Emerg Med 1994; 12: 642–4. PubMed

Pharmacokinetics

Dextromethorphan is rapidly absorbed from the gastrointestinal tract. It is metabolised in the liver and excreted in the urine as unchanged dextromethorphan and demethylated metabolites including dextrorphan (Go to Dextrorphan), which has some cough suppressant activity.

The O-demethylation of dextromethorphan and the hydroxylation of debrisoquine are under common polymorphic control, involving the cytochrome P450 isoenzyme CYP2D6, and dextromethorphan has been used as an alternative to debrisoquine for the phenotyping of oxidative metabolism.1,2 Non-invasive determinations can be made using samples of urine or saliva.3,4 Dextromethorphan has also been suggested as a tool to investigate N-demethylation, an alternate metabolic pathway for this drug.5

  1. 1. Belec L, et al. Extensive oxidative metabolism of dextromethorphan in patients with almitrine neuropathy. Br J Clin Pharmacol 1989; 27: 387–90. PubMed
  2. 2. Streetman DS, et al. Dose dependency of dextromethorphan for cytochrome P450 2D6 (CYP2D6) phenotyping. Clin Pharmacol Ther 1999; 66: 535–41. PubMed
  3. 3. Hildebrand M, et al. Determination of dextromethorphan metabolizer phenotype in healthy volunteers. Eur J Clin Pharmacol 1989; 36: 315–18. PubMed
  4. 4. Hou Z-Y, et al. Salivary analysis for determination of dextromethorphan metabolic phenotype. Clin Pharmacol Ther 1991; 49: 410–19. PubMed
  5. 5. Jones DR, et al. Determination of cytochrome P450 3A4/5 activity in vivo with dextromethorphan N-demethylation. Clin Pharmacol Ther 1996; 60: 374–84. PubMed

Uses and Administration

Dextromethorphan hydrobromide is a cough suppressant used for the relief of non-productive cough; it has a central action on the cough centre in the medulla. It is also an antagonist of N-methyl-d-aspartate (NMDA) receptors. Although structurally related to morphine, dextromethorphan has no classical analgesic properties (but see Pain Go to Pain.) and little sedative activity.

Dextromethorphan hydrobromide is reported to act within half an hour of a dose by mouth and to exert an effect for up to 6 hours. It is given by mouth in doses of 10 to 20 mg every 4 hours, or 30 mg every 6 to 8 hours, to a usual maximum of 120 mg in 24 hours. Children aged 6 to 12 years may be given 5 to 10 mg every 4 hours or 15 mg every 6 to 8 hours to a maximum of 60 mg in 24 hours, and children aged 2 to 6 years 2.5 to 5 mg every 4 hours, or 7.5 mg every 6 to 8 hours, to a maximum of 30 mg in 24 hours. (But see also Cough, Go to Cough..)

Dextromethorphan polistirex (a dextromethorphan and sulfonated diethenylbenzene-ethenylbenzene copolymer complex) is used in modified-release oral preparations. The dosage of dextromethorphan polistirex, expressed as dextromethorphan hydrobromide, is the equivalent of 60 mg every 12 hours; children aged 6 to 12 years may be given 30 mg every 12 hours; children aged 2 to 6 years may be given 15 mg every 12 hours. Dextrorphan (Go to Dextrorphan), the O-demethylated metabolite of dextromethorphan, also has cough suppressant properties.

Cough.

Equal doses of dextromethorphan hydrobromide and codeine phosphate were of similar efficacy in reducing the frequency of chronic cough (Go to Cough) in a double-blind crossover study in adults, but dextromethorphan had a greater effect than codeine on cough intensity.1 However, these drugs were little more effective than placebo in suppressing night-time cough in children.2-4 The American Academy of Pediatrics has commented5 that there is no good evidence for the antitussive efficacy of dextromethorphan in children, that dosage guidelines are derived from (possibly inappropriate) extrapolation from effects in adults, and that adverse effects have been reported.

There is also some evidence that genetic polymorphism in the cytochrome P450 isoenzyme CYP2D6, and hence variations in metabolism, may have a significant influence on the antitussive efficacy of dextromethorphan.6

  1. 1. Matthys H, et al Dextromethorphan and codeine: objective assessment of antitussive activity in patients with chronic cough. J Int Med Res 1983; 11: 92–100. PubMed
  2. 2. Gadomski A, Horton L. The need for rational therapeutics in the use of cough and cold medicine in infants. Pediatrics 1992; 89: 774–6. PubMed
  3. 3. Taylor JA, et al. Efficacy of cough suppressants in children. J Pediatr 1993; 122: 799–802. PubMed
  4. 4. Paul IM, et al. Effect of dextromethorphan, diphenhydramine, and placebo on nocturnal cough and sleep quality for coughing children and their parents. Pediatrics 2004; 114: e85–e90. PubMed
  5. 5. American Academy of Pediatrics Committee on Drugs. Use of codeine- and dextromethorphan-containing cough remedies in children. Pediatrics 1997; 99: 918–20. PubMed
  6. 6. Wright CE, et al. CYP2D6 polymorphism and the anti-tussive effect of dextromethorphan in man. Thorax 1997; 52 (suppl 6): A73.

Neurological disorders.

Dextromethorphan appears to have anticonvulsant activity and may have neuroprotective effects in cerebral ischaemia.1 These effects may be related to its activity as an antagonist of N-methyl-d-aspartate (NMDA) receptors or to interaction with σ-receptors. It has been studied in Parkinson's disease for treatment2 or for management of levodopa-induced dyskinesias,3 and for its potential protective action in stroke and acute brain injury. Dextromethorphan has also been studied for the management of amyotrophic lateral sclerosis (see Motor Neurone Disease, Go to Motor neurone disease.) but has not been found to be of benefit.4-6 A study7 in which quinidine was given to inhibit the metabolism of dextromethorphan did find the combination to be more effective in controlling pseudobulbar affect (emotional lability) than either drug alone, but also associated with more adverse effects. The NMDA-antagonist properties of dextromethorphan have also been investigated for the treatment8,9 of nonketotic hyperglycinaemia (Go to Nonketotic hyperglycinaemia.).

  1. 1. Tortella FC, et al. Dextromethorphan and neuromodulation: old drug coughs up new activities. Trends Pharmacol Sci 1989; 10: 501–7. PubMed
  2. 2. Bonuccelli U, et al. Dextromethorphan and parkinsonism. Lancet 1992; 340: 53. PubMed
  3. 3. Verhagen Metman L, et al. Dextromethorphan improves levodopa-induced dyskinesias in Parkinson's disease. Neurology 1998; 51: 203–6. PubMed
  4. 4. Askmark H, et al. A pilot trial of dextromethorphan in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 1993; 56: 197–200. PubMed
  5. 5. Blin O, et al. A controlled one-year trial of dextromethorphan in amyotrophic lateral sclerosis. Clin Neuropharmacol 1996; 19: 189–92. PubMed
  6. 6. Gredal O, et al. A clinical trial of dextromethorphan in amyotrophic lateral sclerosis. Acta Neurol Scand 1997; 96: 8–13. PubMed
  7. 7. Brooks BR, et al. Treatment of pseudobulbar affect in ALS with dextromethorphan/quinidine: a randomized trial. Neurology 2004; 63: 1364–70. PubMed
  8. 8. Alemzadeh R, et al. Efficacy of low-dose dextromethorphan in the treatment of nonketotic hyperglycinemia. Pediatrics 1996; 97: 924–6. PubMed
  9. 9. Hamosh A, et al. Long-term use of high-dose benzoate and dextromethorphan for the treatment of nonketotic hyperglycinemia. J Pediatr 1998; 132: 709–13. PubMed

Pain.

Dextromethorphan has a potential role in the blockade of pain. It has been investigated1-3 in the management of neuropathic pain with promising results in diabetic neuropathy (Go to Diabetic neuropathy.), although pain was not reduced in postherpetic neuralgia (Go to Postherpetic neuralgia.). High doses of dextromethorphan may be needed for an effect. However, a review4 concluded that there were insufficient data to justify the use of dextromethorphan in diabetic neuropathy and further well-controlled trials were needed.

A systematic review5 of 28 studies of dextromethorphan as an adjunct for postoperative pain found that despite a tendency for patients to report less pain than with placebo, and to use less opioid analgesia postoperatively, the differences tended to be inconsistent and of questionable clinical significance. There was some suggestion that parenteral dextromethorphan was more effective than oral.

  1. 1. Nelson KA, et al. High-dose oral dextromethorphan versus placebo in painful diabetic neuropathy and postherpetic neuralgia. Neurology 1997; 48: 1212–18. PubMed
  2. 2. Sang CN, et al. Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials. Anesthesiology 2002; 96: 1053–61. PubMed
  3. 3. Carlsson KC, et al. Analgesic effect of dextromethorphan in neuropathic pain. Acta Anaesthesiol Scand 2004; 48: 328–36. PubMed
  4. 4. Criner TM, Perdun CS. Dextromethorphan and diabetic neuropathy. Ann Pharmacother 1999; 33: 1221–3. PubMed
  5. 5. Duedahl TH, et al. A qualitative systematic review of peri-operative dextromethorphan in post-operative pain. Acta Anaesthesiol Scand 2006; 50: 1–13. PubMed

Preparations

Single-ingredient Preparations

The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.

Argentina: Dextrotos; Romilar; Australia: Benadryl for the Family Dry Forte¤; Bisolvon Dry; Dexi-Tuss¤; Nucosef DM¤; Robitussin DX; Robitussin Honey Cough Syrup; Strepsils Cough Relief; Tussinol for Dry Coughs¤; Austria: Prontodex; Wick Formel 44 plus Husten-Pastillen; Wick Formel 44 Plus Hustenstiller; Wick Formel 44; Belgium: Actifed; Akindex¤; Benylin Antitussivum¤; Bronchosedal; Dexir; Humex; Nortussine Mono; Pectofree¤; Romilar Antitussivum; Toux-San; Touxium Antitussivum; Tussipect; Tussiphane¤; Tusso Rhinathiol; Vicks Vaposyrup Antitussif; Canada: Balminil DM; Benylin DM; Broncho Grippol DM; Bronchophan DM; Buckley's DM; Calmylin No 1; Centratuss DM¤; Contac Coughcaps¤; Cough Suppressant Syrup DM¤; Cough Syrup DM; Cough Syrup¤; Delsym; DM Children's Cough Syrup; DM Cough Syrup; DM Sans Sucre; Drixoral Cough¤; Drixoral¤; Formula 44; Koffex DM; Koffex¤; Neo-DM¤; Novahistex DM¤; Novahistine DM¤; Ornex-DM¤; Pharmilin-DM; Pharminil DM; Robidex¤; Robitussin Childrens Cough DM; Robitussin Honey Cough DM; Sedatuss DM; Sirop DM¤; Sucrets Cough Control; Syrup DM; Triaminic Cough; Triaminic DM; Tussin Antitussive; Vicks Children's Cough Syrup¤; Chile: Pectobronc; Tusminal; Czech Republic: Dr Rentschler Hustenstiller; Robitussin Antitussicum; Robitussin Junior; Denmark: Dexofan; Finland: Lagun; Resilar; France: Atuxane¤; Bronchytuc¤; Capsyl¤; Codotussyl Toux Seche; Dexir; Drill toux seche; Ergix Toux Seche; Ergix; Fluditec toux seche; Humex Toux Seche Dextromethorphane; Nodex; Pulmodexane; Rhinathiol Toux Seche¤; Sebrane¤; Tussidane; Tuxium; Vicks Toux Seche; Vicks Vaposyrup toux seche¤; Germany: Arpha Hustensirup¤; Em-medical forte; Hustenstiller; NeoTussan; Rheila Hustenstiller¤; Silomat DMP; Tuss Hustenstiller; Wick Formel 44 Husten-Stiller; Wick Formel 44 plus Husten-Pastillen S; Wick Kinder Formel 44 Husten-Stiller¤; Greece: Vaposyrup¤; Hong Kong: Balminil DM¤; Dextrome; Pusiran; Robitussin Maximum Strength Cough; Robitussin Paediatric Cough; Tussils; Hungary: Methor; Robitussin Antitussicum; Robitussin Junior; Wick Formula 44 kohogescillapito; India: Alex Cough; Lastuss; Lexcof; Ireland: Benylin Non-Drowsy Dry Cough; Delsym; Robitussin Dry Cough; Robitussin Junior; Israel: Cough Control Sucrets¤; Tarodex; Italy: Aricodiltosse; Bechilar; Bronchenolo¤; Bronchenolo; Broncofama; Canfodion¤; Fluprim Tosse¤; Formitrol; Gocce Sedative Della Tosse¤; Honeytuss; Lisomucil Tosse Sedativo; Metorfan; Neo Borocillina Tosse Sciroppo; Sanabronchiol¤; Sedotus¤; Simatus¤; Torax¤; Tossoral; Tussycalm; Valatux¤; Vicks Tosse Pastiglie; Vicks Tosse Sedativo; Malaysia: Dexcophan; Metofen Forte¤; Nospan; Pusiran; Tussidex Forte; Tussils; Upha Dextrophan; Mexico: Atassol; Athos; Balbek; Balsedrina; Bekfan¤; Bekidiba Dex; Bioquidan; Brocolan; Debequin; Delsym¤; Dontuxin; Formula S¤; Garde Jarabe¤; Mebran¤; Megal Simple¤; Neo-Ulcoid; Numonyl D; Protan; Quimofan; Romilar¤; Tartrina¤; Tosifan; Versan¤; Netherlands: Benylin-Dextromethorfanhydrobromide¤; Capsyl¤; Dampo bij droge hoest; Darolan Hoestprikkeldempende; Rami-Dextromethorphan; Tosion Retard¤; Vicks Hoestsiroop; Vicks Vaposiroop; Vicks Vapotab; New Zealand: Benadryl Dry Forte; Robitussin DX; Strepsils Cough; Strepsils Dry Cough; Portugal: Akindex¤; Diacol¤; Drill Tosse Seca; Rhinathiol Tosse Seca¤; South Africa: Benylin Dry Cough; Benylin Solid¤; Singapore: Dexcophan; Metophan; Nospan¤; Pusiran; Tussidex¤; Tussils; Spain: Aquitos; Benylin Antitusivo¤; Bexatus; Cinfatos; Formulatus; Frenatus; Gelbronquial¤; Humex¤; Ilvitus; Iniston Antitusivo; Parlatos; Pastillas Dr Andreu; Robitussin DM Antitusivo; Romilar; Serratos; Siepex¤; Streptuss; TIP¤; Tosfriol¤; Tosrhimatiol¤; Tusitinas¤; Tusorama; Tussidrill; Valdatos¤; Sweden: Tussidyl¤; Switzerland: Astho-Med; Bexine; Calmerphan-L; Calmerphan¤; Calmesine; Dextrocalmine¤; Emedrin N; Pharmacard Family Toux seche; Pulmofor; Vicks Formule 44 Calmine; Thailand: Cortuss; Dec¤; Detuss¤; Dex¤; Dextramet; Dextroral; Icolid Plus; Icolid; Polydex; Pusiran; Romilar; Tusco; Tussils; United Arab Emirates: Sedofan P; United Kingdom: Adult Dry Cough; Benylin Dry Coughs Non-Drowsy; Contac Coughcaps¤; Cosylan¤; Covonia for Children¤; Dry Cough Syrup; Franolyn Sedative¤; Meltus Cough Control¤; Nirolex for Dry Coughs¤; Owbridges for Dry Tickly Coughs¤; Robitussin for Dry Coughs; Robitussin Junior¤; Strepsils Cough¤; Vicks Childrens Vaposyrup¤; Vicks Vaposyrup for Dry Coughs; United States: Benylin Adult¤; Benylin DM¤; Benylin Pediatric¤; Children's Hold¤; Congespirin¤; Creo-Terpin; Creomulsion; Delsym; DexAlone; Diabe-Tuss DM; Drixoral Cough¤; ElixSure Childrens Cough; Hold DM; Little Colds Cough Formula; PediaCare Childrens Long-Acting Cough; PediaCare Infants Long-Acting Cough; Pertussin¤; Robitussin Cough Calmers¤; Robitussin Pediatric; Scot-Tussin DM Cough Chasers; Silphen DM; Simply Cough; St. Joseph Cough Suppressant¤; Sucrets 4-Hour Cough¤; Sucrets Cough Control¤; Suppress¤; Theraflu Cough; Triaminic Long Acting Cough; Trocal; Vicks 44 Cough Relief; Vicks Dry Hacking Cough¤; Venezuela: Bromodel; Detofan; Hidrofan; Libolar; Metordex; Mexobron; Promedin; Tilodrin;

Multi-ingredient Preparations

The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.

Argentina: Amiorel Compuesto DM; Antigripal Compuesto; Aseptobron; Benadryl DM Compuesto; Cobenzil Compuesto¤; Mucolitic Antitusivo; Panotos; Selectus; Australia: Actifed CC Junior; Actifed CC¤; Actifed Dry; Adalixin (New Formula)¤; Benadryl Cold and Flu¤; Benadryl for the Family - Dry; Benatuss¤; Benyphed¤; Cepacol Cough & Sore Throat; Chemists Own Dry Raspy Cough¤; Chemists Own Junior Cough & Cold¤; Codral Cough, Cold & Flu Day & Night¤; Coldrex Cold and Flu Capsules¤; Day & Night Cold & Flu; Dimacol¤; Dimetapp Cold & Flu; Dimetapp Cold, Cough & Flu; Dimetapp Cold, Cough & Flu; Dimetapp Cold, Cough & Sinus; Dimetapp DM; Drixine Cough Suppressant¤; Euky Bear Cough Syrup; Formula 44¤; Lemsip Flu; Logicin Cough Mixture for Dry Coughs; Logicin Flu Strength Day & Night; Logicin Flu Strength; Logicin Junior Childrens Cough Mixture; Neo-Diophen; Nyal Decongestant¤; Orthoxicol 1¤; Orthoxicol 8 and 9¤; Orthoxicol Cold & Flu; Orthoxicol Cough Suppressant For Children¤; Orthoxicol Day & Night Cold & Flu; Orthoxicol Dry Cough¤; Orthoxicol Expectorant (with antihistamine)¤; Orthoxicol Expectorant¤; Orthoxicol for Children Nightrest¤; Orthoxicol Night Cold & Flu; Panadol Cold and Flu; Pharma-Col Junior; Prodalix Forte Cough Linctus-New Formula¤; Robitussin DM-P; Robitussin DM; Sigma Relief Junior; Sigma Relief; Triolix Day-time¤; Triolix Night-time¤; Tusselix Cough Silencers¤; Tusselix Liquid¤; Tussinol Cough & Cold¤; Tussinol Day-Time Cough & Cold¤; Tylenol Cold & Flu Non-Drowsy; Tylenol Cold & Flu; Austria: Wick Erkaltungs-Saft fur die Nacht; Wick Hustensaft; Belgium: Acatar¤; Nortussine; Orthoxicol¤; Romilar¤; Vicks Formule 44¤; Brazil: Helifenicol; Silencium; Silencium; Tossbel¤; Xarope 44E; Canada: Actifed DM¤; Antitussive Decongestant Antihistamine Syrup¤; Balminil Cough & Flu; Balminil DM+Decongestant+Expectorant; Balminil DM+Decongestant; Balminil DM+Expectorant; Balminil Night-Time; Benylin 1 Cold and Flu; Benylin DM-D-E; Benylin DM-D; Benylin DM-E; Biohisdex DM¤; Biohisdine DM¤; Bronchodex DM¤; Bronchodex Pediatrique¤; Bronchosirum¤; Buckley's Cough, Cold & Flu Daytime Relief; Buckley's Cough, Cold & Flu Nighttime Relief; Buckley's DM Decongestant; Calmylin Cough & Flu; Calmylin No 2; Calmylin No 3; Calmylin No 4; Calmylin Pediatric; Centracol DM¤; Centracol Pediatrique¤; Centratuss DM Expectorant¤; Centratuss DM-D¤; Childrens NyQuil; Citron Chaud DM; Cold Medication D; Cold Medication Daytime Relief¤; Cold Medication N; Cold Medication Nighttime Relief¤; Contac Cold & Sore Throat; Contac Cough Cold and Flu Day & Night; Contac Cough Cold and Flu¤; Contac Day¤; Cough & Flu Syrup; Cough Syrup DM Decongestant Expectorant; Cough Syrup DM Decongestant for Children; Cough Syrup DM Decongestant; Cough Syrup DM Expectorant; Cough Syrup DM-D-E; Cough Syrup DM-E; Cough Syrup with Guaifenesin & Dextromethorphan; Cough, Cold & Allergy Relief¤; DayQuil; Daytime Cold & Flu¤; Demdec¤; Dimetapp Children's Cough & Cold¤; Dimetapp Cough & Cold Liqui-Gels¤; Dimetapp Cough & Congestion; Dimetapp DM Cough & Cold; DM Cough Syrup Decongestant¤; DM Cough Syrup Expectorant¤; DM Cough Syrup¤; DM Decongestant-Expectorant-Analgesic; DM Decongestant-Expectorant; DM Decongestant; DM E Suppressant Expectorant¤; DM Expectorant Cough; DM Expectorant; DM Plus Decongestant Expectorant; DM Plus Decongestant; DM Plus Expectorant; DM Plus; DM-D Expectorant Cough & Cold; Dorcol DM¤; Extra Strength Cold Medication Daytime Relief; Extra Strength Cold Medication Nightime; Extra Strength Cold Medication Nighttime Relief¤; Formula 44D; Formula 44E; Formula 44M Pediatric¤; Formula 44M¤; Formule 115 DM¤; Histenol Cold; Jack & Jill Cough Cold & Flu; Jack & Jill DM; Junior Strength Cold DM¤; Koffex DM-D-E; Koffex DM-D; Koffex DM-E; Metrate¤; Neo Citran Chest Congestion & Cough; Neo Citran Cough Cold & Flu; Neo Citran Daycaps¤; Neo Citran DM; Neo Citran Sore Throat & Cough; Neo-Tuss; Night-Time; Nighttime Cold & Flu; Novahistex DM Decongestant Expectorant¤; Novahistex DM Decongestant¤; Novahistex DM Expectorant¤; Novahistine DM Decongestant Expectorant¤; Novahistine DM Decongestant¤; Novahistine DM Expectorant¤; NyQuil; Ornade-DM¤; Pediatric Cough Syrup¤; Personnelle Contre le Rhume; Personnelle DM¤; Pharmacol DM¤; Pharminicol DM¤; Pharmitussin DM¤; Promatussin DM¤; Pulmorex DM; Pulmorphan Pediatrique; Pulmorphan; Regular Strength Cold Daytime Relief; Regular Strength Cold Nighttime Relief; Robitussin CF¤; Robitussin Childrens Cough & Cold; Robitussin Cough & Cold; Robitussin Cough, Cold & Flu; Robitussin DM; Robitussin Honey Cough & Cold; Robitussin Honey Flu; Sedatuss¤; Sudafed Cold & Cough; Sudafed Cold & Flu; Sudafed DM¤; Syrup DM-D-E; Syrup DM-D; Syrup DM-E; Tantacol DM¤; Tempra Cold Care¤; TheraFlu Flu, Cold & Cough¤; Trialyn DM; Triaminic Cold & Cough; Triaminic Cold & Fever¤; Triaminic Cold & Nightime Cough; Triaminic Cough & Cold; Triaminic Cough & Congestion; Triaminic Cough & Fever; Triaminic Cough & Sore Throat; Triaminic Cough; Triaminic DM Daytime¤; Triaminic DM Expectorant¤; Triaminic DM Nighttime¤; Triaminic DM-D¤; Triaminic Nighttime Flu¤; Triaminic Throat Pain & Cough; Triaminicol DM¤; Tussin Antitussive, Expectorant, Decongestant; Tussin Children's DM; Tussodan DM; Tylenol Cold & Flu (Nighttime Relief); Tylenol Cold (Chest Congestion); Tylenol Cold (Daytime); Tylenol Cold (Nighttime); Tylenol Cold and Flu Powder; Tylenol Cold DM; Tylenol Cough with Decongestant¤; Tylenol Cough; Tylenol Flu (Daytime Relief); Vasofrinic Plus; Vick's Children's Liquid Nighttime Colds Medicine¤; Vicks Children's Cough and Congestion Syrup¤; Vito Bronches; Chile: Pectobronc Plus; Tusminal Compuesto; Czech Republic: Coldrex Nite; Paralen Plus; Rhinotussal; Rhinotussal; Rhinoval C; Wick Medinait; Finland: Redol Comp; Sir. Ephedrin; France: Actifed Toux Seche¤; Nortussine; Nortussine; Quintopan¤; Tussifed¤; Germany: Basoplex; Contac Erkaltungs-Trunk Forte; Contac H¤; Dorecotuss retard¤; Em-medical; Fluprim¤; Grippostad Gute Nacht-Saft; Husten- und Fieber-Saft¤; Mandro-Gripp¤; Neuridal¤; Noflu F¤; Rhinotussal¤; Robitussin Plus¤; Stoyet¤; sulfopecticept¤; Wick Daymed Erkaltungs; Wick Medinait; Hong Kong: Actifed DM¤; Actihist-Co¤; Bronpect-D; Children's Tylenol Cold Plus Cough¤; Coritussal; Cosyr (Reformulated); Cough-EN¤; Decaugh¤; Dexeryl; Dextro GG; Dextro Plus; DF Night Time; DM-Cordyl; Logicin Cough Mixture for Dry Coughs¤; Logicin Flu Strength Day & Night; Logicin Flu Strength; Logicin Junior Childrens Cough Mixture¤; Marsedyl; Methor-Co; Metoplex; Promethazine Compound Linctus; Robitussin CF¤; Robitussin DM; Sedilix DM¤; Sigma Relief Junior; Sigma Relief; Tuseran; Tylenol Cold¤; Hungary: Rhinoval C; India: Actifed DM; Alex Cough; Alex-P; Alex; Ascoril-D+; Cadicoff; Cheston CS; Clistin; Cof Q; Cof QD; Cofdex CC; Cofdex Forte; Cofdex P; Cofdex Plus; Cofdex; Corex Dx; Cosome; Deletus D; Deletus; Dexcof; Grilinctus; Grilinctus; Lexcof; M&B Cough Syrup; Protussa; Ridcof; Sedosolvin; Sinarest Linctus; Siokof-P; Toff MD; Triaminic CS¤; Tusant¤; Tuspress; Zedex-P; Zedex; Zeet Linctus; Ireland: Actifed Compound; Benylin Childrens Cough and Cold; Benylin Dry Cough; Lotussin¤; Night Nurse; Israel: Actifed DM; Alcinal New; Alcinal Plus; Alcinal; Dexamol Cold Day; Dexamol Cold Night; Paramol AF and Shiul Day; Paramol AF and Shiul Night; Robitussin DM; Tricold¤; Tussocal; Italy: Actifed Composto; Balsatux¤; Benadryl Complex¤; Broncal¤; Bronchenolo; Bronchiase; Bronco-Dex¤; Broncobeta¤; Bronconait¤; Demebronc¤; Euci¤; Honeyflu; Ingro¤; Iodosan¤; Lisoflu¤; Neo Borocillina Tosse Compresse; Neo Borocillina Tosse Gocce¤; Ozopulmin G; Polised; Resyl DM; Romilar¤; Simatus¤; Torfan¤; Torfanolo¤; Tossemed; Tussifama¤; Vicks Medinait; Malaysia: Actifed DM; Actihist-Co; Cough-EN; Dexcophan Cough; Dextrodyl; Dextromethorphan Compound; Flucor Day; Mucolexin¤; Paracetamol Plus Pharmaniaga; Robitussin DM; Sedilix DM; Zainexpect C & F¤; Mexico: Alexing; Alfan; Amgrip; Bectosan; Bekfan-C; Bekidiba; Benciefredil; Bre-A-Col; Brogal-T; Brominol-C; Broncomed¤; Cheracol Duo; CK-2; Co-Exaliv; Co-Tylenol; Cobadex; Contac AM; Contac Ultra; Debequin-C; Dequin; Derofen Miel¤; Desenfriol-Ito TF¤; Dexol; Dimacol; Dimetofan; Dofaxil; Drayacol DX; Dussedrine; Epicol NF¤; Epicol Pediatrico¤; Epicol¤; Eucaliptine; Exalver; Exiadol; Exofil; Faribrox; Flumejoralito Gripe; Histiacil G; Histiacil NF; Megal; Mesorfan; Neopulmonier; Numonyl Tex¤; Oxin; Palmoxan; Ridin; Robitussin DM; Sedalmerck TH¤; Sedevil; Superal Ex; Superal Jarabe; Tesofan-J; TheraFlu Ex; Toa; Torva; Tukol-D; Tusilen Pediatrico; Tusilen; Tylex Flu; Vick 44; Willydina; Yadegal Compuesto; New Zealand: Actifed CC Junior¤; Actifed Dry¤; Benadryl Day & Night¤; Benadryl Dry Cough and Nasal Congestion; Benadryl Nightime; Benylin Cold¤; Cepacol Cough Discs; Codral Cough, Cold & Flu Day & Night¤; Codral Cough¤; Coldrex Flu¤; Coldrex Head & Chest Cold¤; Coldrex Night Relief¤; Day & Night Cold & Flu; Dimetapp Cold & Flu¤; Dimetapp Cold, Cough & Flu Day & Night¤; Dimetapp DM Cold & Cough¤; Lemsip Max Day & Night; Lenactin¤; Orthoxicol Cold & Flu; Orthoxicol Day & Night; Robitussin Children's Night Relief; Robitussin DM-P; Robitussin DM; Robitussin Honey Cold; Vicks Formula 44; Portugal: Antigrippine; Ipesandrine; Russia: Tussin Plus (Туссин Плюс); Zedex (Зедекс); South Africa: Actifed Dry Cough Sugar Free; Acugest DM; Arcanaflu¤; Benylin DM-D; Benyphed¤; Broncol; Cepacol Cough Discs; Cepacol; Coff-Rest¤; Degoran Cough¤; Degoran¤; Demazin Anti-Tussive¤; Dristan Decongestant Cough Medicine; Endcol DM; Flu-Stat; Flusin DM; Histalix-C¤; Kiddyflu; Linctodyl; Lotussin; Medifed; Merck-Flu; Nitecall; Ornacol; Rhinotussal¤; Sinumax Cold & Flu Plus Cough; Vicks Medinite; Singapore: Actifed DM; Coritussal¤; Cough-EN; Dhasedyl DM; Metussa¤; Mucolexin; Panadol for Cold & Flu; Robitussin Cold & Cough; Robitussin Cold, Cough & Flu; Robitussin DM; Sedilix DM; Spain: Benylin Descongestivo; Bronco Medical; Broncoformo Muco Dexa; Cinfatos Complex; Cinfatos Expectorante¤; Diminex Balsamico¤; Espectona Compositum¤; Etermol Antitusivo; Fludren; Frenadol Complex; Frenadol PS; Frenadol; Inistolin Antitusivo Ped; Iniston Antitusivo y Descongestivo; Irritos; Maboterpen¤; Medinait; Mentobox Antitusivo¤; Pectobal Dextro; Propalgina Plus; Propalgina PS Hot Lemon¤; Romilar Expectorante¤; Sudafed Antitusivo¤; Tos Mai; Toscal Compuesto¤; Toscal¤; Tuselin Descongestivo; Vicks Formula 44¤; Vicks Medinait¤; Vincitos; Switzerland: Benical; Brustol¤; Contac Toux¤; Dextrolag¤; Febrinal¤; Hicoseen; Hustex¤; No-Flu¤; Patussol¤; Pharmalyn¤; Pretuval C; Pretuval; Rhinotussal; Rhinotussal; Rivolyn¤; Sirodex¤; Vicks Formel 44¤; Vicks Medinait; Thailand: Actifed DM; Antussia; Antussia; Antust; Benadryl DMP; Boracough; Bronchoprex; Bronpect-D; Brontus; Chinta¤; Chlorhist Cough; Colatus; Coldate¤; Comfy; Contuss¤; Cosyr; D-Coate; Detuss¤; Dexpin; Dextro BS; Dextro; Dextromine; Dimophen¤; Fartussin; Gentussiin; Icolid CPM; Ida-D; Iyafin; Iyafin; Iyafin; Kona; Locko¤; Med-Guaiphan¤; Methorcon; Metussan; Milagin; Muco-DX; Nutacough; PD Cough¤; Pedia-Col; Pharo-Tus¤; Polydine; Presco; Rhinotussal¤; Robitussin DM; Rocal; Rocof¤; Romilar; Rondec-DM¤; Terco-D; Tuscolgen; Tusno; Tussicare; Tussicon¤; United Arab Emirates: Adol Cold; Sedofan DM; United Kingdom: Benylin Childrens Coughs & Colds; Benylin Cough & Congestion; Benylin Dry Coughs Original; Benylin Mentholated Linctus¤; Bronal¤; Bronalin Dry Cough¤; Cabdrivers Sugar-Free Linctus¤; Covonia Bronchial Balsam; Covonia Night-Time; Day & Night Nurse; Flurex¤; Lemsip Night Time¤; Lotussin¤; Meltus Dry Cough; Multi-Action Actifed Dry Coughs; Night Nurse; Nirolex Dry Coughs with Decongestant; Non-Drowsy Sudafed Linctus; Original Cabdrivers Expectorant; Paranorm; Tancolin¤; Vicks Cold Care¤; Vicks Medinite; Vicks Vaposyrup for dry coughs and nasal congestion¤; United States: Accuhist DM Pediatric¤; Accuhist DM Pediatric; Accuhist PDX; Accuhist PDX; Alacol DM; Albatussin NN¤; Albatussin Pediatric¤; Albatussin¤; Alka-Seltzer Plus Cold & Cough¤; Alka-Seltzer Plus Cold & Cough; Alka-Seltzer Plus Night-Time Cold¤; Alka-Seltzer Plus Night-Time Cold; Alka-Seltzer Plus Nose & Throat; All-Nite Cold Formula; Allfen-DM; Ambenyl-D; AMBI 1000/55; AMBI 60/580/30; Amerituss AD; Anaplex DM; Anatuss DM¤; Anatuss¤; Andehist DM¤; Andehist DM; Anextuss; Aquatab C; Aquatab DM; Aspirin-Free Bayer Select Head & Chest Cold; Atuss DM; Atuss-12 DM; Atuss-12 DX; Bayer Children's Cough Syrup¤; Bayer Select Chest Cold; Bayer Select Flu Relief; Bayer Select Night Time Cold; Benylin Expectorant; Benylin Multi-Symptom; Bromadine-DM; Bromarest DX; Bromatan-DM; Bromatane DX; Bromfed-DM; Bromhist PDX; Bromhist PDX; Bromhist-DM; Bromhist-DM; Bromphen DX Cough; Brompheniramine Cough; Brotane DX¤; Carbinoxamine Compound¤; Carbodec DM; Carbodex DM; Carbodex DM; Cardec DM¤; Ceron-DM; Cerose DM; Cheracol D Cough; Cheracol Plus; Children's Formula Cough; Childrens Sudafed Cold & Cough; Chlordex GP; Clear Tussin 30; Co-Apap; Codal-DM; Codimal DM; Cold Relief¤; Coldec DM; Comtrex Day & Night Maximum Strength; Comtrex Day & Night Multi-Symptom; Comtrex Hot Flu Relief; Comtrex Liqui-Gels¤; Comtrex Maximum Strength Night-time Cold & Cough; Comtrex Multi-Symptom Deep Chest Cold; Comtrex; Contac Cough & Chest Cold¤; Contac Cough & Sore Throat¤; Contac Day and Night Cold & Flu Caplets; Contac Night Cold & Flu Caplets¤; Contac Severe Cold & Flu Hot Medicine¤; Contac Severe Cold & Flu Nighttime¤; Contac Severe Cold & Flu Non-Drowsy¤; Contac Severe Cold and Flu Formula¤; Cordron-DM; Corfen-DM; Coricidin HBP Chest Congestion & Cough; Cough Formula Comtrex; Cough Syrup; Cough-X; Cydec DM; Dacex-A; Dacex-DM; Dacex-PE; De-Chlor DM; De-Chlor DR; Decahist-DM; DEKA; Dexafed Cough; Dexcon-DM; Dexcon-PE; Diabetic Tussin DM; Diabetic Tussin; Dimacol; Dimetane DX¤; Dimetapp Decongestant Plus Cough; Dimetapp DM; Dimetapp Long Acting Cough Plus Cold; Dimetapp Nighttime Flu; Dimetapp Non-Drowsy Flu; DMax; Donatussin; Dorcol Children's Cough Syrup; Double-Tussin DM; Dristan Cold & Flu; Dristan Juice Mix-in; Drixoral Cough & Congestion; Drixoral Cough & Sore Throat; Duraflu; Duratuss DM; Effective Strength Cough Formula Liquid With Decongestant; Effective Strength Cough Formula; Extra Action Cough; Extuss; Father John's Medicine Plus; Fenesin DM; Flu, Cold & Cough Medicine; Gani-Tuss-DM NR; GDP-Ex; Genacol; Genatuss DM; Genite; GFN PSE DM; GFN/DM/PE; GFN/DM; Glycotuss-dM; Gripex¤; Guaifenesin DM; Guaifenex DM; Guaifenex Rx DM¤; GuiaCough CF¤; Guiatuss CF¤; Guiatussin with Dextromethorphan; Halotussin-DM¤; Histacol DM; Histenol-Forte; Histine DM¤; Histinex DM¤; Humibid DM; Hydro-Tussin DM; Iobid DM; Iohist DM¤; IoTuss-DM¤; Ipsatol Cough Formula Liquid for Children and Adults¤; Kid Kare Childrens Cough/Cold; Kolephrin GG/DM; Kolephrin/DM; Kophane Cough and Cold Formula¤; Lemotussin-DM; Liqui-Histine DM¤; Lortuss DM; Mapap Cold Formula; Maxifed DM; Maxifed DMX; Maxiphen DM; MED-Rx DM¤; Meda Syrup Forte¤; Medatussin Plus¤; Medatussin¤; Medent-DM; Medi-Flu¤; Medi-Tuss DM¤; Monafed DM; Mucinex DM; Muco-Fen DM; Multi-Symptom Tylenol Cough with Decongestant; Multi-Symptom Tylenol Cough; Myfedrine¤; Myminicol¤; Myphetane DX; Mytussin CF¤; Mytussin DM; Naldecon DX¤; Naldecon Senior DX¤; Naldelate DX Adult¤; Nalspan DX¤; Nalspan Senior DX¤; New Acute Cold Formula¤; Night Time Cold/Flu Relief; Nite Time Cold Formula; Norel SD; Novahistine DMX; Numobid DM¤; NyQuil Hot Therapy; NyQuil Nighttime Cold/Flu; Nytcold Medicine; Ornex Severe Cold No Drowsiness¤; Orthoxicol Cough¤; Panatuss DX; PanMist-DM; PediaCare Childrens Long-Acting Cough Plus Cold; PediaCare Childrens Multi-Symptom Cold; PediaCare Cough-Cold; PediaCare NightRest Cough-Cold Formula; Pediacon DX¤; Pediahist DM; Pediahist DM; Pediatex-DM; Pediatric Formula¤; Pertussin All-Night PM¤; Pertussin AM¤; Phanacol¤; Phanadex Cough¤; Phanatuss Cough; Phenadex Cough/Cold¤; Phenadex Senior¤; Phenameth DM; Phenergan with Dextromethorphan¤; Pherazine DM; Poly-Histine DM¤; Primatuss Cough Mixture 4; Primatuss Cough Mixture 4D; Profen Forte DM; Profen II DM; Prometh with Dextromethorphan; Protuss-DM¤; Pseudo-Car DM; Quelidrine; Recofen-D; Recofen; Relacon Lax; Relacon-DM; Remcol-C¤; Rescon-DM; Respa-DM; Rhinosyn-DM; Rhinosyn-DMX; Rhinosyn-X; Robafen CF¤; Robafen DM; Robitussin CF¤; Robitussin Cold & Cough; Robitussin DM; Robitussin Maximum Strength Cough & Cold; Robitussin Night Relief; Robitussin Pediatric Cough & Cold Formula; Robitussin PM Cough & Cold; Rondamine-DM; Rondec-DM; Ru-Tuss Expectorant¤; Safe Tussin 30; Scot-Tussin Cough & Cold Medicine¤; Scot-Tussin DM; Scot-Tussin Senior Clear; Sildec-DM; Sildec-DM; Siltapp¤; Siltussin DM; Siltussin-CF¤; SINUtuss DM; Snaplets-DM¤; Snaplets-Multi¤; Spec-T¤; Spray-ur-Cold¤; Su-Tuss DM; Suda-Tussin¤; Sudafed Cold & Cough; Sudafed Cough¤; Sudafed Severe Cold; Syn-Rx DM¤; Synacol CF; Syracol CF; Tanafed DM¤; Tanafed DMX; Theracaps¤; TheraFlu Flu & Chest Congestion Non-Drowsy; TheraFlu Flu, Cold & Cough; TheraFlu Non-Drowsy Severe Cold; TheraFlu Severe Cold; Threamine DM¤; Tolu-Sed DM; Touro CC; Touro DM; Triaminic AM Non-Drowsy Cough & Decongestant; Triaminic Cold & Cough; Triaminic Cold & Sore Throat; Triaminic Cough & Sore Throat; Triaminic Cough; Triaminic DM¤; Triaminic Flu, Cough & Fever; Triaminic Night Time Cough & Cold; Triaminic Throat Pain & Cough; Triaminicol Multi-Symptom Cough and Cold¤; Triaminicol Multi-Symptom Relief¤; Tricodene Forte¤; Tricodene NN¤; Tricodene Pediatric Cough & Cold¤; Tricodene Sugar Free; Trihist-DM¤; Trikof-D¤; Triminol Cough¤; Trituss-A; TriTuss; Tusdec-DM; Tusibron-DM; Tusquelin¤; Tuss-DM¤; Tussafed-EX; Tussafed-LA¤; Tussafed¤; Tussall; Tussar DM; Tussi-Organidin DM NR; Tussi-Pres; Tusso-DM¤; Ty-Cold¤; Tylenol Children's Cold Plus Cough; Tylenol Cold Complete Formula; Tylenol Cold Non-Drowsy; Tylenol Cold Severe Congestion; Tylenol Flu Maximum Strength Non-Drowsy; Tylenol Plus Cold & Cough Infants; Uni-tussin DM; Vicks 44 Non-Drowsy Cold & Cough LiquiCaps; Vicks 44D Cough & Head Congestion; Vicks 44E; Vicks 44M Cold, Flu & Cough LiquiCaps; Vicks Children's NyQuil Night-time Cold/Cough Liquid; Vicks Cough Silencers¤; Vicks DayQuil Cold/Flu Relief; Vicks Formula 44 Cough Control Discs¤; Vicks NyQuil LiquiCaps; Vicks NyQuil Multi-Symptom Cold Flu Relief; Vicks Pediatric Formula 44D Dry Hacking Cough & Head Congestion¤; Vicks Pediatric Formula 44E; Vicks Pediatric Formula 44M Multi-Symptom Cough & Cold; Viravan-DM; Viro-Med¤; Vitanumonyl Pediatric¤; Vitanumonyl¤; Z-Cof; Venezuela: Aurimel; Dextonil; Hidrofan; Metorfedrin; Preveral con Dextrometorfano; Promedina; Robitessindem; Teratos; Yonal;



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