Cyamemazine

Cyamemazine

Drug Nomenclature

Date of monograph revision: 18-Mar-1998; 23-Jun-2000; 13-Nov-2001; 13-Feb-2004; 14-Apr-2005; 22-Jun-2006
Synonyms: Ciamemazina; Cyamepromazine; RP-7204
INN: Cyamemazine [rINN (en)]
INN: Ciamemazina [rINN (es)]
INN: Cyamémazine [rINN (fr)]
INN: Cyamemazinum [rINN (la)]
INN: Циамемазин [rINN (ru)]
Chemical name: 10-(3-Dimethylamino-2-methylpropyl)phenothiazine-2-carbonitrile
Molecular formula: C19H21N3S =323.5
CAS: 3546-03-0 (cyamemazine); 93841-82-8 (cyamemazine tartrate)
ATC code: N05AA06
Chemical Structure of Cyamemazine

Chemical Structure of Cyamemazine

Drug Profile

Cyamemazine is a phenothiazine with general properties similar to those of chlorpromazine (Go to Chlorpromazine). It is used in the management of a variety of psychiatric disorders including anxiety disorders (Go to Anxiety disorders) and aggressive behaviour (Go to Disturbed behaviour.).

Cyamemazine has been given by mouth as the base or the tartrate and by injection as the base. Doses are expressed in terms of the base; cyamemazine tartrate 36.6 mg is equivalent to about 25 mg of cyamemazine. Doses have ranged from 25 to 600 mg daily by mouth, depending on the individual and the condition being treated; the daily dosage is given in 2 or 3 divided doses with the larger amount at night. Doses given by intramuscular injection have ranged from 25 to 200 mg daily.

Cyamemazine should be given in reduced dosage to elderly patients; the parenteral route is not recommended for the elderly.

Preparations

Single-ingredient Preparations

The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.

France: Tercian; Portugal: Tercian;

Multi-ingredient Preparations

The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.

Germany: Neutromil¤;



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