Betamethasone

Betamethasone

Drug Nomenclature

Date of monograph revision: 09-Jun-1997; 07-Jul-1998; 25-Feb-2000; 17-Aug-2001; 04-Mar-2004; 19-Jul-2006
Synonyms: 9α-Fluoro-16β-methylprednisolone; β-Methasone; Beetametasoni; Betadexamethasone; Betametason; Betametasona; Betametazon; Betametazonas; Betamethason; Betamethasonum; Flubenisolone; Flubenisolonum; NSC-39470; Sch-4831
BAN: Betamethasone
USAN: Betamethasone
INN: Betamethasone [rINN (en)]
INN: Betametasona [rINN (es)]
INN: Bétaméthasone [rINN (fr)]
INN: Betamethasonum [rINN (la)]
INN: Бетаметазон [rINN (ru)]
Chemical name: 9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione
Molecular formula: C22H29FO5 =392.5
CAS: 378-44-9
ATC code: A07EA04; C05AA05; D07AC01; H02AB01; R01AD06; R03BA04; S01BA06; S02BA07; S03BA03
Read code: y02Yj
Chemical Structure of Betamethasone

Chemical Structure of Betamethasone

NOTE:

Use in Sport. Betamethasone may be restricted in certain sports, see Go to Drugs in Sport, as it is considered to be a member of a prohibited group (Glucocorticoids (excluding dermatological preparations)); competitors should check with the appropriate sports authorities.

Pharmacopoeias:

In Chin., Eur. (see Go to European Pharmacopoeia Convention Signatories), Int., Jpn, and US.

Ph. Eur. 5.5 (Betamethasone). A white or almost white, crystalline powder. Practically insoluble in water; sparingly soluble in dehydrated alcohol; very slightly soluble in dichloromethane. Protect from light.

USP 29 (Betamethasone). A white to practically white, odourless, crystalline powder. Soluble 1 in 5300 of water, 1 in 65 of alcohol, 1 in 15 of warm alcohol, 1 in 325 of chloroform, and 1 in 3 of methyl alcohol; sparingly soluble in acetone and in dioxan; very slightly soluble in ether. Store in airtight containers at a temperature between 2 degrees and 30 degrees.

Betamethasone Acetate

Drug Nomenclature

Date of monograph revision: 09-Jun-1997; 07-Jul-1998; 25-Feb-2000; 17-Aug-2001; 04-Mar-2004; 19-Jul-2006
Synonyms: Beetametasoniasetaatti; Betametasona, acetato de; Betametasonacetat; Betametazon-acetát; Betametazono acetatas; Betamethason-acetát; Betamethasoni Acetas
BAN: Betamethasone Acetate [BANM]
INN: Betamethasone Acetate [rINNM (en)]
INN: Acetato de betametasona [rINNM (es)]
INN: Bétaméthasone, Acétate de [rINNM (fr)]
INN: Betamethasoni Acetas [rINNM (la)]
INN: Бетаметазона Ацетат [rINNM (ru)]
Chemical name: Betamethasone 21-acetate
Molecular formula: C24H31FO6 =434.5
CAS: 987-24-6
ATC code: A07EA04; C05AA05; D07AC01; H02AB01; R01AD06; R03BA04; S01BA06; S02BA07; S03BA03

NOTE:

Use in Sport. Betamethasone Acetate may be restricted in certain sports, see Go to Drugs in Sport, as it is considered to be a member of a prohibited group (Glucocorticoids (excluding dermatological preparations)); competitors should check with the appropriate sports authorities.

Pharmacopoeias:

In Eur. (see Go to European Pharmacopoeia Convention Signatories) and US.

Ph. Eur. 5.5 (Betamethasone Acetate). A white or almost white, crystalline powder. Practically insoluble in water; soluble in alcohol and in dichloromethane; freely soluble in acetone. It shows polymorphism. Protect from light.

USP 29 (Betamethasone Acetate). A white to creamy-white, odourless powder. Soluble 1 in 2000 of water, 1 in 9 of alcohol, and 1 in 16 of chloroform; freely soluble in acetone. Store in airtight containers at a temperature between 2 degrees and 30 degrees.

Betamethasone Benzoate

Drug Nomenclature

Date of monograph revision: 09-Jun-1997; 07-Jul-1998; 25-Feb-2000; 17-Aug-2001; 04-Mar-2004; 19-Jul-2006
Synonyms: Betametasona, benzoato de; W-5975
BAN: Betamethasone Benzoate [BANM]
USAN: Betamethasone Benzoate
INN: Betamethasone Benzoate [rINNM (en)]
INN: Benzoato de betametasona [rINNM (es)]
INN: Bétaméthasone, Benzoate de [rINNM (fr)]
INN: Betamethasoni Benzoas [rINNM (la)]
INN: Бетаметазона Бензоат [rINNM (ru)]
Chemical name: Betamethasone 17α-benzoate
Molecular formula: C29H33FO6 =496.6
CAS: 22298-29-9
ATC code: A07EA04; C05AA05; D07AC01; H02AB01; R01AD06; R03BA04; S01BA06; S02BA07; S03BA03

NOTE:

Use in Sport. Betamethasone Benzoate may be restricted in certain sports, see Go to Drugs in Sport, as it is considered to be a member of a prohibited group (Glucocorticoids (excluding dermatological preparations)); competitors should check with the appropriate sports authorities.

Pharmacopoeias:

In US.

USP 29 (Betamethasone Benzoate). A white to practically white, practically odourless, powder. Insoluble in water; soluble in alcohol, in chloroform, and in methyl alcohol. Store in airtight containers at a temperature between 2 degrees and 30 degrees.

Betamethasone Dipropionate

Drug Nomenclature

Date of monograph revision: 09-Jun-1997; 07-Jul-1998; 25-Feb-2000; 17-Aug-2001; 04-Mar-2004; 19-Jul-2006
Synonyms: Beetametasonidipropionaatti; Betametasona, dipropionato de; Betametasondipropionat; Betametazon-dipropionát; Betametazono dipropionatas; Betamethason-dipropionát; Betamethasoni Dipropionas; Sch-11460
BAN: Betamethasone Dipropionate [BANM]
USAN: Betamethasone Dipropionate
INN: Betamethasone Dipropionate [rINNM (en)]
INN: Dipropionato de betametasona [rINNM (es)]
INN: Bétaméthasone, Dipropionate de [rINNM (fr)]
INN: Betamethasoni Dipropionas [rINNM (la)]
INN: Бетаметазона Дипропионат [rINNM (ru)]
Chemical name: Betamethasone 17α,21-dipropionate
Molecular formula: C28H37FO7 =504.6
CAS: 5593-20-4
ATC code: A07EA04; C05AA05; D07AC01; H02AB01; R01AD06; R03BA04; S01BA06; S02BA07; S03BA03

NOTE:

Compounded preparations of betamethasone dipropionate may be represented by the following names:

Co-climasone (PEN)—clotrimazole and betamethasone dipropionate.

Use in Sport. Betamethasone Dipropionate may be restricted in certain sports, see Go to Drugs in Sport, as it is considered to be a member of a prohibited group (Glucocorticoids (excluding dermatological preparations)); competitors should check with the appropriate sports authorities.

Pharmacopoeias:

In Eur. (see Go to European Pharmacopoeia Convention Signatories), Jpn, and US.

Ph. Eur. 5.5 (Betamethasone Dipropionate). A white or almost white, crystalline powder. Practically insoluble in water; sparingly soluble in alcohol; freely soluble in acetone and in dichloromethane. Protect from light.

USP 29 (Betamethasone Dipropionate). A white to cream-white, odourless powder. Insoluble in water; sparingly soluble in alcohol; freely soluble in acetone and in chloroform. Store in airtight containers at a temperature of 25 degrees, excursions permitted between 15 degrees and 30 degrees.

Betamethasone Sodium Phosphate

Drug Nomenclature

Date of monograph revision: 09-Jun-1997; 07-Jul-1998; 25-Feb-2000; 17-Aug-2001; 04-Mar-2004; 19-Jul-2006
Synonyms: Beetametasoninatriumfosfaatti; Betametasona, fosfato sódico de; Betametasonnatrifosfatum; Betametazon-nátrium-foszfát; Betametazono natrio fosfatas; Betamethason-fosfát sodná sůl; Betamethasone Disodium Phosphate; Betamethasoni Natrii Phosphas
BAN: Betamethasone Sodium Phosphate [BANM]
INN: Betamethasone Sodium Phosphate [rINNM (en)]
INN: Fosfato sódico de betametasona [rINNM (es)]
INN: Bétaméthasone, Phosphate Sodique de [rINNM (fr)]
INN: Natrii Betamethasoni Phosphas [rINNM (la)]
INN: Натрия Бетаметазона Фосфат [rINNM (ru)]
Chemical name: Betamethasone 21-(disodium phosphate)
Molecular formula: C22H28FNa2O8P =516.4
CAS: 360-63-4 (betamethasone phosphate); 151-73-5 (betamethasone sodium phosphate)
ATC code: A07EA04; C05AA05; D07AC01; H02AB01; R01AD06; R03BA04; S01BA06; S02BA07; S03BA03
Read code: y00nz [Ear]; y036U [Nose]; y00l3 [Eye]

NOTE:

BET is a code approved by the BP 2005 for use on single unit doses of eye drops containing betamethasone sodium phosphate where the individual container may be too small to bear all the appropriate labelling information.

Use in Sport. Betamethasone Sodium Phosphate may be restricted in certain sports, see Go to Drugs in Sport, as it is considered to be a member of a prohibited group (Glucocorticoids (excluding dermatological preparations)); competitors should check with the appropriate sports authorities.

Pharmacopoeias:

In Eur. (see Go to European Pharmacopoeia Convention Signatories), Jpn, and US.

Ph. Eur. 5.5 (Betamethasone Sodium Phosphate). A white or almost white, very hygroscopic, powder. Freely soluble in water; slightly soluble in alcohol; practically insoluble in dichloromethane. A 1% solution in water has a pH of 7.5 to 9.0. Store in airtight containers. Protect from light.

USP 29 (Betamethasone Sodium Phosphate). A white to practically white, odourless, hygroscopic, powder. Soluble 1 in 2 of water and 1 in 470 of alcohol; freely soluble in methyl alcohol; practically insoluble in acetone and in chloroform. Store in airtight containers.

Betamethasone Valerate

Drug Nomenclature

Date of monograph revision: 09-Jun-1997; 07-Jul-1998; 25-Feb-2000; 17-Aug-2001; 04-Mar-2004; 19-Jul-2006
Synonyms: Beetametasonivaleraatti; Betametasona, valerato de; Betametasonvalerat; Betametazon-valerát; Betametazono valeratas; Betamethason-valerát; Betamethasoni Valeras
BAN: Betamethasone Valerate [BANM]
USAN: Betamethasone Valerate
INN: Betamethasone Valerate [rINNM (en)]
INN: Valerato de betametasona [rINNM (es)]
INN: Bétaméthasone, Valérate de [rINNM (fr)]
INN: Betamethasoni Valeras [rINNM (la)]
INN: Бетаметазона Валерат [rINNM (ru)]
Chemical name: Betamethasone 17α-valerate
Molecular formula: C27H37FO6 =476.6
CAS: 2152-44-5
ATC code: A07EA04; C05AA05; D07AC01; H02AB01; R01AD06; R03BA04; S01BA06; S02BA07; S03BA03
Read code: y00Bk

NOTE:

Use in Sport. Betamethasone Valerate may be restricted in certain sports, see Go to Drugs in Sport, as it is considered to be a member of a prohibited group (Glucocorticoids (excluding dermatological preparations)); competitors should check with the appropriate sports authorities.

Pharmacopoeias:

In Eur. (see Go to European Pharmacopoeia Convention Signatories), Int., Jpn, US, and Viet.

Ph. Eur. 5.5 (Betamethasone Valerate). A white or almost white, crystalline powder. Practically insoluble in water; soluble in alcohol; freely soluble in acetone and in dichloromethane. Protect from light.

USP 29 (Betamethasone Valerate). A white to practically white, odourless, powder. Practically insoluble in water; soluble 1 in 16 of alcohol, 1 in less than 10 of chloroform, and 1 in 400 of ether; freely soluble in acetone; slightly soluble in benzene. Store in airtight containers.

Adverse Effects, Treatment, Withdrawal, and Precautions

As for corticosteroids in general (see Go to Adverse Effects of Corticosteroids and their Treatment).

Betamethasone has little or no effect on sodium and water retention.

When applied topically, particularly to large areas, when the skin is broken, or under occlusive dressings, or when given intranasally, corticosteroids may be absorbed in sufficient amounts to cause systemic effects. Prolonged use of ophthalmic preparations containing corticosteroids has caused raised intra-ocular pressure and reduced visual function.

Anosmia.

Complete anosmia was reported in 2 patients after the use of nasal drops containing betamethasone and neomycin sulfate1 and, in one patient, showed no sign of resolving 1 year later. The reaction was thought to be due to the preservative thiomersal present in the drops, although it was noted that neomycin could exert a toxic effect on the olfactory mucosa and that there have been several reports of anosmia associated with the use of betamethasone alone.

  1. 1. Whittet HB, et al. Anosmia due to nasal administration of corticosteroid. BMJ 1991; 303: 651. PubMed

Interactions

The interactions of corticosteroids in general are described on Go to Interactions of Corticosteroids.

Pharmacokinetics

For a brief outline of the pharmacokinetics of corticosteroids, see Go to Pharmacokinetics of Corticosteroids. Betamethasone crosses the placenta.

Uses and Administration

Betamethasone is a corticosteroid with mainly glucocorticoid activity (Go to Introduction); the anti-inflammatory activity of 750 micrograms of betamethasone is equivalent to about 5 mg of prednisolone. It has been used, either in the form of the free alcohol or in one of the esterified forms, in the treatment of conditions for which corticosteroid therapy is indicated (Go to Uses and Administration of Corticosteroids), except adrenal-deficiency states for which hydrocortisone with supplementary fludrocortisone is preferred. Its virtual lack of mineralocorticoid properties makes betamethasone particularly suitable for treating conditions in which water retention would be a disadvantage.

The dose is usually expressed in terms of the base, and the following are each equivalent to about 1 mg of betamethasone:

betamethasone acetate 1.1 mg

betamethasone benzoate 1.3 mg

betamethasone dipropionate 1.3 mg

betamethasone sodium phosphate 1.3 mg

betamethasone valerate 1.2 mg

When given by mouth betamethasone or betamethasone sodium phosphate is used; the usual dose, expressed in terms of betamethasone, ranges from 0.5 to 5 mg daily.

For parenteral use the sodium phosphate ester may be given intravenously by injection or infusion or intramuscularly by injection in doses equivalent to 4 to 20 mg of betamethasone. It may also be given by local injection into soft tissues in doses equivalent to 4 to 8 mg of betamethasone. Doses in children, as a slow intravenous injection, are:

infants aged up to 1 year: the equivalent of 1 mg of betamethasone

1 to 5 years: 2 mg

6 to 12 years: 4 mg

Doses may be repeated 3 or 4 times in 24 hours if necessary, depending on the condition being treated and the clinical response. The sodium phosphate ester is also sometimes used with the acetate or dipropionate esters, which have a slower and more prolonged action.

Betamethasone sodium phosphate is also used in the topical treatment of allergic and inflammatory conditions of the eyes, ears, or nose, usually as drops or ointment containing 0.1%.

For topical application in the treatment of various skin disorders the dipropionate and valerate esters of betamethasone are extensively used; the usual concentrations available are the equivalent of 0.05% of betamethasone as the dipropionate, and 0.025 or 0.1% as the valerate. For recommendations concerning the correct use of corticosteroids on the skin, and a rough guide to the clinical potencies of topical corticosteroids, see Go to Topical application..

Betamethasone valerate has also been used by inhalation for the prophylaxis of asthma.

Other esters of betamethasone which have occasionally been used include the benzoate, butyrate propionate, phosphate, salicylate (cortobenzolone), and valero-acetate.

Betamethasone adamantoate has been used in veterinary practice.

Haemangioma.

For reference to the use of a mixture of betamethasone and triamcinolone for the intralesional injection of haemangiomas, see Go to Haemangioma.

Inflammatory bowel disease.

For a comparison of betamethasone and beclometasone enemas in the treatment of ulcerative colitis, see under Beclometasone, Go to Inflammatory bowel disease.. Corticosteroids are one of the mainstays of treatment of inflammatory bowel disease, the general management of which is discussed on Go to Inflammatory bowel disease.

Neonatal respiratory distress syndrome.

For a discussion on the antenatal use of betamethasone to prevent neonatal respiratory distress syndrome, see Go to Neonatal respiratory distress syndrome.

Preparations

Single-ingredient Preparations

The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.

Argentina: Beta Adenil¤; Betacort; Betacort; Betasone-G 12 Horas; Betasone-G; Betatopic; Betnovate; Blacor; Butasona RL; Butasona; Celestone Cronodose; Celestone; Cevicort; Corteroid Retard; Corteroid; Cortiderma; Cortimar; Cronocorteroid; Cronolevel; Deltalaf; Dermizol; Diprocel¤; Diprosone; Maxisona; Micosep B; Quiacort; Transderma B; Valederm; Australia: Antroquoril; Betnovate; Celestone Chronodose; Celestone M; Celestone V¤; Celestone¤; Cortival; Diprosone; Eleuphrat; Austria: Betnesol; Betnovate; Celestan; Diproderm; Diproforte; Diprophos; Solu-Celestan; Belgium: Betnelan-V; Betnesol¤; Celestone Chronodose; Celestone; Diprolene; Diprosone; Brazil: Alersan; Bebyderm¤; Beclonato; Benevat; Beta Long; Betaderm; Betametagen; Betaprospan; Betaspan; Betnelan; Betnolon; Betnovate; Betrat B; Betsona; Celestan; Celestone Soluspan; Celestone; Dermobet; Dermonil; Dermoval¤; Dermovat; Dermovate¤; Dibetam; Diprobeta; Diprocort; Diprosone; Diprospan; Duoflam; Epidermil¤; Sensitex; Valbet; Canada: Beben¤; Betacort¤; Betaderm; Betagel¤; Betaject; Betnesol; Betnovate¤; Celestoderm; Celestone Soluspan; Celestone¤; Diprolene Glycol; Diprosone; Novobetamet¤; Occlucort¤; Prevex B; ratio-Ectosone; ratio-Topilene; Rholosone¤; Rhoprolene¤; Rhoprosone¤; Rivasone¤; Rolene¤; Rosone¤; Taro-Sone; Topisone¤; Valisone; Chile: Betnovate; Cidoten Rapilento; Cidoten V; Cidoten; Coritex; Cremirit; Cronolevel; Dacam RL; Dacam; Diprolene; Diprospan; Diprospan; Disopranil; Konicortil; Labosona; Oftasona P; Spel; Czech Republic: Beloderm; Beta; Betnovate; Celestoderm-V; Diprophos; Diprosone; Kuterid; Denmark: Betnovat; Betoid¤; Bettamousse; Celeston¤; Celeston; Celeston; Diproderm; Diprolen; Diprospan; Finland: Bemetson; Betapred; Betnovat; Bettamousse¤; Celestoderm; Celeston Chronodose; Diproderm; Diprolen; France: Betnesol; Betneval; Celestene Chronodose; Celestene; Celestoderm; Diprolene; Diprosone; Germany: Bemon; Beta-Stulln; Beta-Wolff; Betacort¤; BetaCreme; Betagalen; Betam-Ophtal; BetaSalbe; Betnesol-V; Betnesol-WL¤; Betnesol¤; Betnesol; Celestamine N; Celestan Depot; Celestan solubile; Celestan-V; Celestan¤; Cordes Beta; Diprosis; Diprosone Depot; Diprosone; durabetason¤; Euvaderm¤; Lygal E Creme¤; Pentacort¤; Soderm; Greece: Betamatic¤; Betnovate; Celestene; Celestoderm-V; Celestone Chronodose; Flogozyme; Galinocort; Locason-N; Locason¤; Movithiol; Osmoran; Propiochrone; Propioform; Sanorvil; Hong Kong: Betaderma; Betasone; Betazone; Betnovate; Celestoderm-V¤; Celestone¤; Derzid; Diprocel; Diprosone; Diprospan; Ectosone¤; Topilene¤; Hungary: Celestone; Diprophos; India: Betafoam; Betnecip; Betnecort; Betnederm; Betnelan; Betnesol; Betnovate; Topicasone; Valbet; Walacort; Ireland: Betacap; Betnelan; Betnesol; Betnovate; Bettamousse; Diprosone; Israel: Betacorten; Betnesol; Betnovate; Bettamousse; Celestoderm-V¤; Celestone Chronodose; Dicorten¤; Diprolene; Diprosone; Diprospan; Italy: Beben; Bedermin¤; Bentelan; Beta 21; Betamesol; Bettamousse; Celestoderm-V; Celestone Cronodose; Celestone; Diprosone; Ecoval; Minisone¤; P 10¤; Paucisone¤; Malaysia: Beavate; Beprogel; Beprosone; Besone; Beta; Betasone; Betnesol¤; Betnosone; Betnovate; Bufencon; Celestoderm-V; Celestone; Dermasole DP¤; Dermasole¤; Dibetasol; Diprocel; Diprosone; Diprospan; Setrosone¤; Uniflex; Mexico: Betnovate; Celestoderm-V¤; Celestone Soluspan; Celestone; Cronolevel; Dermoval; Diprosone; Diprospan; Netherlands: Betnelan; Betnesol; Celestoderm; Celestone Chronodose; Celestone; Diprolene; Diprosone; Norway: Betnovat; Betoid¤; Bettamousse; Celeston¤; Celeston; Diproderm; New Zealand: Beta; Betnesol; Betnovate; Bivate; Celestone Chronodose; Diprolene; Diprosone; Portugal: Betnasol; Betnovate; Celesdepot; Celestone; Cilestoderme; Dibetop¤; Diprofos; Diprosone; Soluderme; Vabeta; Russia: Akriderm (Акридерм); Betasone (Бетазон); Celestoderm-V (Целестодерм-В); Diprospan (Дипроспан); South Africa: Betanoid; Betnelan¤; Betnesol; Betnovate; Celestoderm-V; Celestone Soluspan; Celestone; Diprolene; Diprosone; Lenasone; Lenovate; Persivate; Repivate; Steromien¤; Topivate; Singapore: Beprogel; Beprosone; Besone; Betacorten; Betasone; Betnovate; Celestoderm-V; Celestone; Dermasone; Derzid; Dibetasol; Diprocel; Diprosone; Diprospan; Medobeta¤; Uniflex¤; Spain: Betamatil¤; Betnovate; Bettamousse; Celestoderm-V; Celestoderm; Celestone Cronodose; Celestone; Diproderm; Sclane¤; Tuplix¤; Sweden: Betapred; Betnovat; Betoid¤; Bettamousse; Celeston bifas; Celeston valerat; Celeston¤; Celeston; Diproderm; Diprolen; Switzerland: Betnesol; Betnovate; Celestoderm-V; Celestone Chronodose; Celestone; Diprolene; Diprosone; Thailand: Bennasone; Beprogel; Bepronate; Beprosone; Besone; Bessasone; Beta; Betameth; Bethasone; Betnovate; Betosone; Bipro; Celestoderm-V¤; Celestone¤; Derzid; Diprobet; Diprosone; Diprospan; Diprotop; Prevex B; Sebo; Valbet; Valerbet; United Arab Emirates: Betasone; Betasone; United Kingdom: Betacap; Betnelan; Betnesol; Betnovate RD (Ready Diluted); Betnovate; Bettamousse; Bextasol¤; Diprosone; Vista-Methasone; United States: Alphatrex¤; B-S-P¤; Beta-Val; Betatrex¤; Cel-U-Jec; Celestone Soluspan; Celestone; Diprolene; Diprosone; Luxiq; Maxivate; Psorion¤; Selestoject¤; Teladar; Uticort¤; Valisone; Venezuela: Betaderm; Betagen Solspen; Betagen; Betnovate; Celestoderm; Celestone Soluspan; Celestone; Detarmon; Diprocel; Diprosone; Diprospan; Itisona;

Multi-ingredient Preparations

The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.

Argentina: Adenil; Algio Nervomax Fuerte; Antiflogol; Antihemorroidal; Bacticort Complex; Bacticort; Becortin; Betacort Plus; Betasalic; Betasone-G Compuesto; Betnovate Antihemorroidal¤; Betnovate-C; Betnovate-N; Blokium B12; Calmurid; Celestamine-L; Celestamine; Cevaderm; Ciprocort L; Clarityne Cort; Confor-Tar¤; Corteroid Gesic; Cortispec; Cortistamin L; Cortistamin NF¤; Cuta Crema; Denvercrem; Dermizol G; Dermizol Trio; Dermosona; Dermovit¤; Dioxaflex B12; Diprogenta; Diprosalic; Eubetal Biotic¤; Factor Dermico; Fucicort; Fusimed B; Gelbiotic Plus; Gentasol; Hifamonil Crema; Histamino Corteroid L; Lazar-Cort Complex; Lisaler Beta; Lotricomb; Macril; Maxisalic; Mencogrin¤; Mencogrin; Micomazol B; Miklogen; Monizol Cort Crema; Negalerg¤; Neo-Mudapenil; Nularef Cort; Oxa B12; Procto-Metadyne; Quadriderm CD; Quadriderm¤; Quiacort G Plus; Quiacort G; Sinaler B; Sirotamicin BG; Sorsis Beta; Tribiocort; Triliver; Triplex; Vesalion B12; Virobron B12 NF; Vitacortil; Vixidone LB; Xedenol B12; Australia: Celestone VG¤; Daivobet; Austria: Betnesol-N; Betnovate-C; Betnovate-N; Celestamin; Diprogenta; Diprosalic; Psorcutan Beta; Belgium: Betnelan-VC; Betnelan-VN¤; Celestamine-F¤; Diprophos; Diprosalic; Fucicort; Garasone; Lotriderm; Brazil: Betazol Cort; Betazon¤; Betnovate-N; Betnovate-Q; Candicort; Celestamil; Celestamine; Cetobeta; Cetocort; Cetocorten; Cremederme; Dermosalic; Dextamine; Dipro AS; Diprogenta; Diprosalic; Emscort; Garasone; Gentacort; Microbiogen; Novacort; Oto Betnovate; Poliderms; Postec; Quadriderm; Quadrikin; Quadrilon; Quadriplus; Qualiderm; Reumix; Tetraderm; Verutex B; Canada: Betnovate-N¤; Celestone S¤; Diprogen¤; Diprosalic; Dovobet; Garasone; Lotriderm; ratio-Topisalic; SAB-Pentasone; Valisone-G; Chile: B-Laboterol; Betnovate-N; Cam; Celestamine; Cestop B; Clofexan; Clotrimin-B; Cobefen; Contralmor; Creminem-B; Deucoaler; Diproquin; Diprosalic; Diprospan G; Donomix; Fucicort; Gentasone; Gotalgic; Labosalic; Labosona G; Labosona N¤; Locrim; Lotriderm; Mixgen; Novadrel; Novarnela; Oftagen Compuesto; Oftasona N; Otandrol; Otazol; Oticum; Otolisan; Plexus; Prodel B; Vilterm; Czech Republic: Belogent; Belosalic; Betabioptal; Diprosalic; Fucicort; Garasone; Lotriderm; Denmark: Betnovat med Chinoform; Betnovat Rektal¤; Celeston med Chinoform; Clotrason; Daivobet; Diproform¤; Diprosalic; Fucicort; Finland: Bemetson-K; Betnovat Comp; Betnovat-C; Celestoderm cum Chinoform; Celestoderm cum Garamycin; Daivobet; Diprosalic; Fucicort; France: Betnesalic¤; Betneval-Neomycine¤; Celestamine; Celestoderm Neomycine¤; Daivobet; Diprosalic; Diprosept; Diprosone Neomycine; Diprostene; Gentasone¤; Glido Neomycine¤; Glido¤; Germany: Betadermic; Betagentam; Betamethason Plus¤; Betnesalic¤; Betnesol-VN¤; Betnesol¤; Celestamine¤; Daivobet; Dermobeta; Diprogenta; Diprosalic; durabetagent¤; Euvaderm N¤; Euvaderm¤; Fenistil Plus¤; Fucicort; Lotricomb; Lygal E Tinktur¤; Psorcutan Beta; Ralena¤; Soderm Plus; Sulmycin mit Celestan-V; Terracortril N; Greece: Betacort; Betnovate-C; Betnovate-N; Dovobet; Fucicort; Garamat; Propiogenta; Propiosalic; Hong Kong: Allersan; Bechlomin; Beclomin¤; Becogem; Betnesalic¤; Betnovate-C¤; Betnovate-N; Bonjedex; Celestamine; Celestoderm-V with Garamycin; Celestoderm-V with Neomycin¤; Clobeta-G; Conazole; Daivobet; Dermafacte; Derzid-C; Derzid-N; Dexmin¤; Diprogenta; Diprosalic; Fucicort; Garasone; Lozopin; Lycobeta-G; Quadriderm; Synbetamine; Triderm; Hungary: Diprosalic; Fucicort; Garasone; Vipsogal; India: Betamil-M; Betasalic; Betnederm C; Betnederm GM; Betnederm N; Betnesol-N Nasal; Betnesol-N; Betnor; Betnovate-C; Betnovate-GM; Betnovate-M; Betnovate-N; Betnovate-S; Fourderm AF; Fourderm; Genticyn B Eye/Ear; Quiss; Supirocin-B; Surfaz-SN; Topicasone with Neomycin; Valbet; Ireland: Betnesol-N; Betnovate-C; Betnovate-N; Diprosalic; Diprosone Duopack¤; Dovobet; Fucibet; Lotriderm; Vista-Methasone N¤; Israel: Betacorten-G; Betnesol-N; Betnovate-C; Betnovate-N; Celestoderm-V with Garamycin¤; Daivobet; Diprogenta; Diprosalic; Fucicort; Triderm; Italy: Alfaflor; Antibioticoedermin B¤; Apsor¤; Beben Clorossina; Bentelan¤; Betabioptal; Betafloroto; Biorinil; Brumeton Colloidale S; Deltavagin; Dermatar; Diproform; Diprogenta¤; Diprorecto¤; Diprosalic; Dovobet; Ecoval con Neomicina; Eubetal Antibiotico; Eubetal Antibiotico; Eubetal¤; Fluororinil; Fucicort; Gentalyn Beta; Micomplex¤; Micutrin Beta; Psorinase; Rinojet¤; Stranoval; Token; Viobeta¤; Visublefarite; Visumetazone Antibiotico; Visumidriatic Antiflogistico¤; Malaysia: Beavate N; Beprogent; Beprosalic; Besone-N; Betacin; Betagen; Betamethasone Clo; Betamethasone G; Betamethasone N; Betamethasone SA; Betnesol-N¤; Betnosone N; Betnovate-N; Celestoderm-V with Garamycin; Diprogenta; Diprosalic; Fobancort; Fucicort; Fusidic B; Garasone; Joysun; Triderm-C; Uniflex-N; Mexico: Artridol; Betrigen; Celestamine NS; Celestamine-F¤; Celestamine; Claricort¤; Clio-Betnovate; Diprosalic¤; Diprosone G; Diprosone Y; Fucicort; Garamicina-V; Garasone; Gelmicin; Genrex-B¤; Miclobet; Prubagen; Quadriderm NF; Tamex; Triderm; Netherlands: Betnelan Clioquinol¤; Betnelan Neomycine¤; Betnelan-VC¤; Betnelan-VN¤; Celestoderm met Garamycin¤; Celestoderm met Neomycine¤; Celestoform¤; Diprosalic; Dovobet; Norway: Betnovat med Chinoform; Daivobet; Diprosalic; New Zealand: Betnesol Aqueous; Betnesol-N¤; Betnovate-C; Daivobet; Diprosalic¤; Fucicort; Lotricomb¤; Ultrazon N¤; Portugal: Beta-Micoter; Betnovate-C; Betnovate-N; Daivobet; Dibetop Q¤; Diprogenta; Diprosalic; Epione; Flotiran; Fucicort; Psodermil; Quadriderme; Russia: Akriderm GK (Акридерм ГК); Akriderm SK (Акридерм СК); Betagenot (Бетагенот); Celestoderm-V with Garamycin (Целестодерм-В с Гарамицином); Diprosalic (Дипросалик); Fucicort (Фуцикорт); Triderm (Тридерм); South Africa: Betanoid N; Betnesol-N; Betnovate-C; Betnovate-N; Celestamine; Celestoderm-V with Garamycin; Diprogenta; Diprosalic; Garasone¤; Lotriderm; Quadriderm; Singapore: B-Tasone-G¤; Beprogent; Beprosalic; Besone-N; Betnovate-C¤; Betnovate-GM¤; Betnovate-M¤; Betnovate-N¤; Bufencon¤; Celestoderm-V with Garamycin; Celestoderm-V with Neomycin; Clotrasone; Combiderm; Conazole; Daivobet; Dermanol-C; Diprogenta; Diprosalic; Fobancort; Fucicort; Garasone; Gentrisone; Neoderm; Quadriderm; Tri-Micon; Triderm; Uniflex-N¤; Spain: Alergical; Beta Micoter; Beta Micutrin¤; Betamatil con Neomicina¤; Betamida¤; Betartrinovo¤; Bronsal; Celesemine; Celestoderm Gentamicina; Celestone S; Clotrasone; Cuatroderm; Daivobet; Diprogenta; Diprosalic; Fucibet; Nasotic Oto¤; Otocusi Enzimatico¤; Ramatocina¤; Raquivit¤; Resorborina¤; Sclamine¤; Sclane¤; Visublefarite¤; Sweden: Betnovat med Chinoform; Betnovat med Neomycin; Celeston valerat comp¤; Celeston valerat med chinoform; Celeston valerat med gentamicin; Daivobet; Diprosalic; Switzerland: Betnesalic; Betnovate-C; Betnovate-N; Celestamine; Daivobet; Diprogenta; Diprophos; Diprosalic; Fucicort; Ophtasone; Quadriderm; Triderm; Thailand: Bacda-B; Benn¤; Beprogenta; Besone-N; Beta-C; Beta-Dipo; Beta-N; Beta-S; Betama-EN¤; Betameth-N; Bethasone-N; Betnesalic; Betnovate-C; Betnovate-N; Betosalic; Betosone-CE; Canasone; Canazol-BE; Celestoderm-V with Neomycin¤; Clotrasone; Daivobet; Derzid-C; Derzid-N; Diprogenta; Diprosalic; Fucicort; Fungiderm-B; Gynesten-B; Myda-B; Quadriderm¤; Topaben-N; Twina; Valbet-N; United Arab Emirates: Futasone; Supraproct-S; United Kingdom: Betnesol-N; Betnovate Rectal Ointment¤; Betnovate-C; Betnovate-N; Diprosalic; Dovobet; Fucibet; Lotriderm¤; Vipsogal; Vista-Methasone N; United States: Lotrisone; Taclonex; Venezuela: Betaderm con Gentamicina; Celestamine; Celestoderm con Gentalyn; Claricort; Diproformo; Diprogenta; Diprosalic; Garabet; Garasone; Lotricomb; Lotrisone; Propioformo; Propiogenta; Propiosalic; Quadriderm; Triderm; Tridetarmon; Urisalic; Vio Celestoderm;



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